患有严重急性胰腺炎的患者的肝素耐药性:一个病例报告
Dai Rongqin1, Bai Zhexin2, Liu Yuzhi1
1Department of Medical Technology, Cangzhou Medical College, Cangzhou, China.
Laboratory medicine
|April 16, 2025
概括
严重的急性胰腺炎患者可能会发展出肝素耐药性,这是一个罕见的并发症. 这一案例表明,当肝素失败时,里瓦洛克萨班成功控制了血栓形成,强调对有效的抗凝固药物进行监测.
科学领域:
- 关键护理医学 关键护理医学
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 严重的急性胰腺炎由于系统性炎症和静脉血栓症等并发症而带来高死亡风险.
- 氨酸耐药性虽然不常见,但在未分离氨酸治疗期间可能会损害抗凝疗效果,使患者管理复杂化.
研究的目的:
- 报告严重急性胰腺炎中对肝素耐药性的病例.
- 为了说明诊断挑战和成功的管理策略,非抗素介导的氨酸耐药性.
主要方法:
- 一名患有严重急性胰腺炎的患者经历了持续的亚疗法激活的部分血栓塑时间,尽管升级了未分离的肝素剂量.
- 实验室分析显示,抗素水平正常,抗Xa活性无法检测,证实了氨酸耐药性并非由抗素缺乏症介导.
主要成果:
- 诊断出非抗红素介导的肝素耐药性.
- 一个多学科的团队成功地使用Rivaroxaban管理了患者的血栓形成,导致显著的临床改善.
结论:
- 在严重的急性胰腺炎中,早期识别和治疗肝素耐药性至关重要.
- 监测激活的部分血栓塑时间和抗Xa活性对于优化抗凝和预防深静脉血栓形成至关重要.
相关概念视频
01:30Acute Pancreatitis II: Clinical Manifestations and Management
72
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
72
01:27Acute Pancreatitis I: Introduction
264
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
264
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
548
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
548
01:24Chronic Pancreatitis I: Introduction
56
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
56
01:29Chronic Pancreatitis II: Collaborative Care
50
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
50