针对癌症相关的糖基化,用于固体瘤的采用性T细胞疗法
Andreas Zingg1, Reto Ritschard1, Helen Thut1
1University of Basel, Basel, Switzerland.
Cancer immunology research
|April 16, 2025
概括
一种全新的全人类仿真抗原受体 (CAR) T细胞疗法向西-托姆森-纽沃 (STn) 抗原,显示出治疗卵巢和胰腺癌等上皮癌的前景.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 葡萄糖生物学 葡萄糖生物学
背景情况:
- 化学抗原受体 (CAR) T细胞疗法对B细胞恶性瘤有效.
- 使用CAR-T细胞治疗固体瘤是具有挑战性的,因为异质的抗原表达.
研究的目的:
- 开发一种全人类的CAR T细胞疗法,针对在分泌表皮癌中发现的STn抗原.
- 在临床前模型中评估抗STn CAR T细胞的疗效和安全性.
主要方法:
- 产生了一个完全人类的CAR,准了sialyl-Thomsen-Nouveau (STn) 抗原.
- 在使用特定抗体的各种瘤组织中评估STn抗原表达.
- 在体外和体内临床前模型中测试了抗STn CAR T细胞,包括原发性卵巢癌样本.
主要成果:
- 在显著比例的胃肠道 (胰腺) 和妇科 (卵巢,子宫内膜) 癌症中观察到强烈的STn表达.
- 抗STn CAR T细胞在临床前模型中表现出活性.
- 在小鼠模型中没有观察到显著的毒性,在小鼠肠道组织中观察到最小的异抗原表达.
结论:
- 全人类抗STn CAR构造显示出对表皮癌的前临床活性有前途.
- 在早期临床试验中,对这种针对STn.的新型CAR T细胞疗法进行进一步评估是有必要的.
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