Z-选择性合成三替代基因的HWE反应使用修改的Still-Gennari类型试剂
1Division of Organic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, ul. Sienkiewicza 112, 90-363 Łódź, Poland.
新的酸试剂使得高效的三替代基的Z选择性合成成为可能. 这种修改后的Horner-Wadsworth-Emmons油性化为各种基结构提供了高产量和出色的Z-选择性.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
- 立体选择性合成 立体选择性合成
背景情况:
- 霍纳-瓦兹沃斯-埃蒙斯反应是烯合成的关键方法.
- 在三替代合成中实现高Z选择性仍然是一个挑战.
- 新型试剂的开发对于推进立体选择性精制方法至关重要.
研究的目的:
- 引入和评估用于基合成的新酸试剂.
- 通过修改的Horner-Wadsworth-Emmons油性化实现三替代的Z选择性合成.
- 评估这些试剂在一系列基质的疗效,包括肉酸.
主要方法:
- 作为新型试剂,使用了乙基二 ((1,1,1,3,3,3-hexafluoroisopropyl) phosphonoalkanoates.
- 采用了经过修改的Horner-Wadsworth-Emmons碳烯烯酸精制协议.
- 合成了各种三替代基,包括Z-2-aryl替代的酸.合成了各种三替代基.
主要成果:
- 获得的三位置换Z-基具有非常高的量化产量.
- 对合成的烯表现出极好的Z-选择性.
- 即使在高温下,也证实了酸合成的独特Z选择性.
结论:
- 新型酸试剂对Z选择性烯合成非常有效.
- 修改后的霍纳-瓦兹沃斯-埃蒙斯反应提供了一条可靠的途径,以获得有价值的Z-基.
- 这种方法提供了一种可靠的方法来合成Z-2-aryl替代的酸.
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