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在男性创伤患者 (POWeR-MTP) 中实用O-阳性全血随机测试

Anthony M Strada¹, Gus Suarez², Xian Luo-Owen³

¹Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

European journal of trauma and emergency surgery : official publication of the European Trauma Society

|April 16, 2025

概括

在创伤患者中,低位数O阳性全血 (LTOWB) 与组件疗法 (CT) 相比,显示出减少输血需求的趋势. 具体来说,LTOWB在接受出血控制干预 (HCI) 的患者中显著减少了红细胞输血 (PRBC).

科学领域:

创伤复苏的复苏治疗方法
大规模输血协议.
紧急医疗紧急医疗

背景情况:

出血仍然是创伤相关死亡的主要原因.
低位数O阳性全血 (LTOWB) 为传统组分疗法 (CT) 提供了一个潜在的替代方案.
这项研究将需要紧急输血的创伤患者的LTOWB与CT进行比较.

研究的目的:

评估LTOWB是否减少创伤患者的输血需求.
评估LTOWB对死亡率的影响.
分析在接受血液控制干预 (HCI) 的患者的输血需求.

主要方法:

需要不匹配输血的成年男性创伤患者被随机分配到接受LTOWB或CT.
排除标准包括女性,儿童和囚犯.
主要结局是24小时输血需求,对HCI患者进行子集分析.

主要成果:

与CT相比,LTOWB患者倾向于减少PRBC,FFP和冷流体输血.
接受LTOWB治疗的接受HCI治疗的患者的PRBC输血显著减少 (p=0.013).
在LTOWB和CT组之间,死亡率相似 (10.2%对10.5%).

结论:

LTOWB与创伤患者接受HCI的PRBC输血减少有关.
对于LTOWB,观察到总体输血减少PRBC,FFP和冷沉积物的趋势.
在特定的创伤场景中,LTOWB代表了组件治疗的可行替代方案.

关键词:

组件疗法是一种组件疗法.低位数的O-阳性全血全血小组.大规模的输血输血.创伤性出血性冲击是创伤性的出血性冲击.

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