在乳头甲状腺癌中BRAF p.V600E突变的患病率和临床影响
Alexandria Brumfield1, Sara Abou Azar2, Rachel Nordgren3
1School of Medicine, Case Western Reserve University, 9501 Euclid Ave, Cleveland, OH, 44106, USA.
Endocrine pathology
|April 16, 2025
概括
BRAF p.V600E突变在乳头甲状腺癌 (PTC) 中很常见,但不能独立预测复发. 其他因素,如节点疾病负担和男性性别是PTC复发的更重要的预测因素.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 病理学 病理学 病理学
背景情况:
- 确定侵袭性乳头甲状腺癌 (PTC) 治疗的危险因素至关重要.
- 讨论了BRAF p.V600E突变在PTC预后中的作用.
- 了解突变特异性风险是个性化PTC管理的关键.
研究的目的:
- 调查BRAF p.V600E突变与PTC中的临床病理特征之间的关联.
- 确定BRAF p.V600E突变是否是PTC复发的独立预测因素.
- 评估BRAF p.V600E在PTC风险分层中的临床意义.
主要方法:
- 301名PTC患者 (2018-2022) 进行了BRAF p.V600E测试后期分析.
- 数据收集包括BRAF状态,瘤亚型,TN类别,瘤大小,结节负担和复发.
- 使用多变量Cox比例危险模型来评估复发预测因素.
主要成果:
- 在78.7%的患者中存在BRAF p.V600E突变,并与特定的PTC亚型 (经典,高细胞) 相关.
- BRAF p.V600E与瘤大小或结节疾病负担无关.
- 大结节疾病负担 (HR 3.37) 和男性性别 (HR 2.29) 显著预测了复发; BRAF p.V600E没有 (HR 0.71).
结论:
- 仅仅BRAF p.V600E突变本身并没有显著影响PTC复发风险.
- 当考虑其他临床病理因素时,其在PTC风险分层中的有用性是可疑的.
- 节点疾病负担和男性性别是PTC复发的更关键指标.
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