当体重重要时:肥胖如何影响生殖健康和怀孕-系统性审查
Konstantina Barbouni1, Vaidas Jotautis2, Dimitra Metallinou1
1Midwifery Department, Faculty of Health & Care Sciences, University of West Attica, 12243, Egaleo, Athens, Greece.
Current obesity reports
|April 16, 2025
概括
肥胖会对男性和女性的生育能力,辅助生殖技术 (ART) 的成功和怀孕健康产生负面影响. 怀孕前体重管理和量身定制的护理对于更好的生殖结果至关重要.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 遗传学 遗传学 是一个
背景情况:
- 肥胖是一个全球性的健康问题,对生殖健康有重大影响.
- 了解肥胖对生育能力和怀孕的多方面的影响,对于临床实践至关重要.
研究的目的:
- 系统地审查肥胖对男性和女性生殖健康的影响.
- 评估肥胖对辅助生殖技术 (ART) 结果的影响.
- 综合有关肥胖相关妊娠并发症和代际健康影响的证据.
主要方法:
- 按照PRISMA指南进行系统的文献搜索.
- 包括35项专注于肥胖和生殖结果的研究.
- 对荷尔蒙,代谢和表观遗传机制的分析,这些机制将肥胖与不孕症和不良妊娠结果联系起来.
主要成果:
- 肥胖会破坏荷尔蒙平衡 (例如,减少SHBG,丸激素),增加胰岛素抵抗,促进炎症,损害生育能力和ART的成功.
- 孕产妇的肥胖增加了妊娠糖尿病,妊娠前,剖腹产和新生儿并发症的风险.
- 父亲肥胖和母亲肥胖通过表观遗传修饰导致代谢功能障碍.
结论:
- 肥胖对生殖健康,ART疗效和怀孕结果构成重大风险.
- 孕前体重管理,个性化的ART和量身定制的产前护理是必不可少的.
- 需要进一步研究男性不孕症,针对肥胖的优化ART和代际影响.
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