在囊性染细胞瘤中,囊内甲醇胺的变化
Tomoko Fujii1,2, Hironori Bando3,4, Masaaki Yamamoto1,2
1Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, 7-5-2, Kusunoki, Chuo, Kobe, Kobe, 650-0017, Japan.
Journal of endocrinological investigation
|April 16, 2025
概括
囊性染细胞瘤显示出不同的甲基醇胺和甲基氨酸水平. 囊液的测量可能并不总是与周围血液的发现相匹配或与瘤中的PNMT酶表达相关.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 生物化学 生物化学
背景情况:
- 囊性染细胞瘤约占所有染细胞瘤的20%.
- 有限的研究存在于囊性液体和外周血液中的甲基胺和甲基氨酸部分之间的相关性.
研究的目的:
- 研究囊性染细胞瘤患者的外周血液和囊性液体中的甲胺分离物及其代谢物之间的关系.
主要方法:
- 对5名患有病理诊断的囊性叶红细胞瘤的患者的分析.
- 在囊性液体中测量甲基胺分子和代谢物.
- 评估基乙醇胺N-甲基转移酶 (PNMT) 在瘤组织中的表达及其与囊性液类甲醇胺的关系.
主要成果:
- 在两名患者身上观察到囊性液体和周围血液中甲基胺和甲基尼的持续升高模式.
- 在两名患者中观察到异常,尽管囊性液中甲基胺含量升高,但在周围血液中诺米坦尼林占主导地位.
- 在大多数情况下,PNMT表达与外周血液中的甲醇胺相关,但与囊性液体中的甲醇胺分离物不一致.
结论:
- 囊性花色细胞瘤囊中的catecholamine分数升高模式可能与外周血液水平不一致.
- 囊性液体中的甲基胆胺概况可能与瘤组织中的PNMT表达不一致.
相关概念视频
Adrenergic Neurons: Neurotransmission
3.2K
Postganglionic sympathetic fibers (except those supplying the sweat glands) releasing noradrenaline or norepinephrine are called noradrenergic or adrenergic neurons. Noradrenaline, dopamine, adrenaline, or epinephrine are collectively called "catecholamines" as they contain a catechol moiety and an amine side chain. The five stages of neurotransmitter release involve their synthesis, storage, release, reuptake and metabolism.
Synthesis: Catecholamine synthesis requires tyrosine, which...
Synthesis: Catecholamine synthesis requires tyrosine, which...
3.2K
Adrenal Gland Disorders
1.2K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.2K
Drugs Affecting Neurotransmitter Release or Uptake
876
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
876
Adrenergic Receptors: ɑ Subtype
1.3K
Adrenoceptors are classified into α and ꞵ classes based on their potencies to catecholamine agonists. α-adrenoceptors show the following order of catecholamine potency:
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
1.3K
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla
1.1K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
1.1K
Adrenergic Receptors: β Subtype
1.4K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
1.4K


