性,神经网络和行为症状 青少年多部位疼痛
Esmeralda Hidalgo-Lopez1,2, Tristin Smith2, Mike Angstadt3
1Department of Psychology, University of Michigan, Ann Arbor.
JAMA network open
|April 16, 2025
概括
青少年多部位疼痛与大脑连接和行为问题的改变有关,在男性和女性中观察到独特的模式. 患有疼痛的女性的睡眠障碍可能部分归因于感觉运动网络连接的减少.
科学领域:
- 神经科学是一个神经科学.
- 青少年健康 青少年健康
- 疼痛研究 疼痛研究
背景情况:
- 多部位疼痛在青春期不成比例地影响女性,通常与中枢神经系统失调有关.
- 了解与多部位疼痛相关的多种神经网络和行为症状对于有效治疗至关重要.
研究的目的:
- 研究青少年多部位疼痛中静止状态神经网络的性别特异性.
- 检查与多部位疼痛的年轻人的神经网络特征相关的同时发生的睡眠和行为问题.
主要方法:
- 从青少年大脑和认知发展研究中对2052名青少年 (11-12岁) 的横截面分析.
- 在突出网络,感觉运动网络和默认模式网络中对静止状态功能连接的性别分层分析.
- 评估行为问题和睡眠障碍,以及它们与大脑网络密度的关联.
主要成果:
- 多部位疼痛与男性和女性的感官运动网络 (SMN) 内连接性降低有关.
- 患有多部位疼痛的男性显示出增加的默认模式网络 (DMN) -SMN连接,而女性则表现出增加的睡眠障碍.
- 减少SMN内部连接部分解释了女性青少年睡眠障碍和疼痛之间的关联.
结论:
- 与性有关的神经生理机制与青少年的多部位疼痛有关.
- 大脑连接的差异部分介于女性的睡眠与疼痛的关联,这表明有针对性的干预措施.
- 对持久性发现的进一步研究可能会支持对患有疼痛的青少年女性睡眠障碍的干预.
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