在患有急性淋巴细胞白血病的青少年和年轻成年人中接受符合指南的治疗
Julie A Wolfson1,2, Allison C Grimes3, Michelle M Nuño4,5
1Division of Pediatric Hematology-Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.
JNCI cancer spectrum
|April 16, 2025
概括
患有急性淋巴细胞白血病 (ALL) 的青少年和年轻人在儿科设施中更经常接受符合指导方针的护理. 改善成人设施的沟通和通道可以加强对这个年龄组的照顾.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 临床研究 临床研究
背景情况:
- 患有急性淋巴细胞白血病 (ALL) 的15-39岁的青少年和年轻人 (AYA) 经历了较差的生存率和独特的治疗挑战.
- 评估了国家癌症研究所社区瘤研究计划 (NCORP) 的实践,以确定影响ALL患者AYA护理的设施级因素.
研究的目的:
- 评估设施层面的因素,以及对被诊断患有ALL的AYA患者的护理与既定指南的一致性.
- 在AYA ALL治疗中确定设施模型,患者数量和指导方针一致的护理之间的关联.
主要方法:
- 分析了在NCORPs (2012-2016) 接受ALL治疗的AYA (15-39岁) 的回顾性队列.
- 用患者数据和设施问卷来评估与国家综合癌症网络指导方针 (儿科启发的治疗或临床试验) 的治疗一致性.
- 采用了通用线性混合效应模型,以根据设施类型和患者数量估计接受指导方针一致护理的几率.
主要成果:
- 与指导方针一致的护理在年轻的AYA (平均年龄19.5岁) 与老年AYA (平均年龄32.1岁) 相比更常见.
- 在成人/内科医疗机构接受治疗的AYA获得指导方针一致的护理的几率明显较低 (OR=0.02).
- 在AYA ALL患者的年体积和指南一致的护理之间没有发现显著的关联. 成人/混合设施中的沟通和特定途径与更好的坚持相关.
结论:
- 设施模型,特别是成人/内部医学设置,是影响针对ALL的AYA患者的指导方针一致护理的重要因素,独立于患者数量.
- 加强成人和儿科护理团队之间的沟通,建立专门的临床途径,并在成人机构进行AYA特定会议是改善护理一致性的关键策略.
关键词:
艾亚艾亚艾亚艾亚是什么意思NCCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN急性淋巴细胞白血病急性淋巴细胞白血病青少年 青少年 青少年 青少年工厂的设施设施的设施.准则 准则 准则提供医疗保健服务.医院 医院 医院 医院服务是服务的服务.年轻的成年人年轻的成年人更多相关视频
06:08Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Published on: February 10, 2023
1.2K
09:57Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
29.1K
相关概念视频
01:22Bone Marrow Sampling and Transplants
263
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
263
02:50Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K