来自乳杆菌科的后生物保护肠道屏障功能,在使用结肠有机管道的挑战模型中
Colin I Cercamondi1, Igor Bendik1, Erik Eckhardt1
1DSM-Firmenich AG, Wurmisweg 576, 4303 Kaiseraugst, Switzerland.
Foods (Basel, Switzerland)
|April 16, 2025
概括
这项研究表明,一种来自Limosilactobacillus fermentum和Lactobacillus delbrueckii亚种的后生物. 乳糖可以加强肠道屏障. 它增强了上皮的恢复,并以剂量依赖的方式降低了炎症性细胞因子.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 来自有益细菌的后生物质越来越多地被认为具有潜在的健康益处.
- 保持肠道屏障的完整性对于肠道健康和预防炎症至关重要.
- 乳酸菌种以其益生菌和促进健康的特性而闻名.
研究的目的:
- 研究一种特定的后生物对肠上皮质屏障功能和细胞因子生产的影响.
- 在人类结肠器官模型中评估后生物质的剂量依赖性疗效.
- 确定后生菌对药物诱导的上皮损伤和炎症反应的影响.
主要方法:
- 人类衍生的结肠管在芯片上培养,并用阿法替尼治疗以诱导上皮质屏障破坏.
- 一种来自Limosilactobacillus fermentum和Lactobacillus delbrueckii亚种的后生物. 乳糖在不同度 (5,10,20毫克/毫升) 中使用.
- 通过上皮电阻 (TEER) 和相对照成像用于评估屏障完整性,同时测量细胞因子水平.
主要成果:
- 与对照组相比,所有测试后生物度都显著改善了TEER恢复.
- 较高的后生物剂量 (10和20毫克/毫升) 对TEER恢复表现出更明显的效果.
- 最高剂量 (20 mg/mL) 显著降低了一系列的促炎细胞因子,表明向抗炎特征的转变.
结论:
- 乳杆菌系衍生后生物在结肠有机体模型中有效保护药物诱导的上皮损伤.
- 后生菌证明了上皮质屏障恢复和功能的剂量依赖增强.
- 这种后生物调节细胞因子分泌,促进肠道内的抗炎环境.
关键词:
牛乳杆菌 (Lactobacillus delbrueckii) 是一种植物.这就是 Limosilactobaccilus 发酵.细胞因子 细胞因子肠道屏障 肠道屏障 肠道屏障有机体管道是有机体管道.后生物学的后生物.更多相关视频
12:11Identification of Metabolically Active Bacteria in the Gut of the Generalist Spodoptera littoralis via DNA Stable Isotope Probing Using 13C-Glucose
Published on: November 13, 2013
15.3K
10:20Linking Predation Risk, Herbivore Physiological Stress and Microbial Decomposition of Plant Litter
Published on: March 12, 2013
13.2K
相关概念视频
00:58Symbiosis
27.0K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
27.0K
00:46Bioremediation
18.1K
Bioremediation is the use of prokaryotes, fungi, or plants to remove pollutants from the environment. This process has been used to remove harmful toxins in groundwater as a byproduct of agricultural run-off and also to clean up oil spills.
18.1K
00:54What are Biogeochemical Cycles?
30.7K
The most common elements in organic molecules, carbon, hydrogen, oxygen, nitrogen, sulfur, and phosphorus, are only available in the ecosystem in limited amounts. Therefore, these nutrients must be recycled through both biotic and abiotic components of the ecosystem, in processes generally called biogeochemical cycles.
30.7K
01:39Keystone Species
21.4K
Measures of species biodiversity, such as richness (i.e., the number of species present) and evenness (i.e., their relative abundance), describe an ecological community’s structure. Many factors affect community structure, including abiotic factors (e.g., sunlight and nutrients), disturbances (e.g., fire or flood), species interactions (e.g., predation or competition), and chance events (e.g., foreign species invasion). Certain species—such as keystone species—also play a...
21.4K
02:26Defenses Against Pathogens and Herbivores
22.3K
Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
22.3K
02:39Predator-Prey Interactions
16.0K
Predators consume prey for energy. Predators that acquire prey and prey that avoid predation both increase their chances of survival and reproduction (i.e., fitness). Routine predator-prey interactions elicit mutual adaptations that improve predator offenses, such as claws, teeth, and speed, as well as prey defenses, including crypsis, aposematism, and mimicry. Thus, predator-prey interactions resemble an evolutionary arms race.
16.0K