量化生物库和队列研究的影响
Rodrigo Dorantes-Gilardi1,2, Kerry L Ivey1,3,4, Lauren Costa1
1Million Veteran Program Coordinating Center, Veterans Affairs Boston Healthcare System, Boston, MA 02130.
概括
生物库通过提供样本和数据来加速研究. 开放性和质量数据,特别是链接的医疗记录,显著增加了生物银行.
科学领域:
- 生物医学研究生物医学研究
- 这是生物银行.
- 数据科学数据科学数据科学
背景情况:
- 生物库对于研究至关重要,但它们的影响有所不同.
- 目的,范围,治理和数据的差异影响生物库的影响.
研究的目的:
- 以计算方式识别生物库并分析其使用情况.
- 描述利用生物库的学术社区.
- 识别导致生物库影响的因素.
主要方法:
- 确定了2,663个生物库及其在科学文献,赠款,专利,临床试验和政策文件中的提及.
- 分析了针对特定疾病 (肥胖,阿尔茨海默病,乳腺癌,糖尿病) 的研究重点.
- 使用了通用线性模型来确定影响生物库影响的因素.
主要成果:
- 生物库的研究集中在几个关键疾病上.
- 合作,而不是引用数量,推动了生物银行的认可.
- 41.1%的文章没有引用生物银行参考,而59.6%的文章包括生物银行合著者.
- 对外部研究人员的开放性和质量数据 (链接医疗记录) 与更高的影响相关.
结论:
- 生物库的影响受到可访问性和数据质量的影响.
- 链接的医疗记录比大量的数据更具影响力.
- 调查结果为提高生物银行获取和价值的策略提供了信息.
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