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肠道病毒中的单一突变会改变热带性和对微生物群的敏感性

Andrea K Erickson¹, Danica M Sutherland^2,3, Olivia L Welsh^2,3

¹Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390.

Proceedings of the National Academy of Sciences of the United States of America

|April 16, 2025

概括

微生物群枯竭对肠道病毒感染的影响不同. 一些reovirus菌株在没有肠道细菌的情况下更好地复制,而另一些则被抑制,揭示了复杂的病毒-宿主-微生物群相互作用.

科学领域:

病毒学病毒学
微生物学微生物学
免疫学免疫学免疫学

背景情况:

肠道微生物群影响肠道病毒感染,经常带来好处.
然而,包括轮状病毒和轮状病毒在内的Reovirales病毒对微生物群组成的反应各不相同.

研究的目的:

调查微生物群枯竭如何影响特定的reovirus菌株的复制.
根据病毒菌株和宿主反应,阐明不同感染结果背后的机制.

主要方法:

使用了一对同源的reovirus菌株 (T3SA+和T3SA-),它们的σ1附着蛋白不同.
在微生物群枯竭后,对小鼠的病毒复制和感染结果进行了评估.
研究了酸结合和III型干扰素反应的作用.

主要成果:

微生物群的枯竭减少了转型病毒菌株T3SA+的感染,但增加了T3SA-菌株的感染.
T3SA+利用酸结合用于肠内皮细胞感染.
肠道上皮细胞中的微生物驱动的III型干扰素反应限制了T3SA感染.

结论:

与微生物群和宿主抗病毒防御的REOVIRUS菌株特定相互作用决定了感染结果.
病毒附着蛋白多态性在微生物群调节的背景下显著影响热带和复制.
了解这些复杂的相互作用对于预测病毒病原和宿主反应至关重要.

关键词:

肠道病毒肠道病毒干扰子干扰子干扰子我们的微生物群.复原病毒的复原病毒酸是酸的一种.

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