饮食多样性改变了Per和Polyfluoroalkyl物质与加速生物衰老的关联:来自中国国家人类生物监测研究的证据
Zheng Zhang1,2, Nan Sheng3, Yingli Qu1,2
1China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Environmental science & technology
|April 16, 2025
概括
和多醇基物质 (PFAS) 与加速的生物衰老有关. 更高的饮食多样性评分 (DDS) 可能会减轻这些有害影响,这表明饮食的保护作用.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 老年学是一门学科.
背景情况:
- 和多醇基物质 (PFAS) 是广泛存在的环境污染物,已知对健康有影响.
- PFAS对人类生物衰老的影响尚不清楚.
- 了解这些关联对于公共卫生和风险评估至关重要.
研究的目的:
- 调查PFAS暴露与生物衰老之间的关联.
- 评估饮食多样性评分 (DDS) 在这种关系中的调节作用.
- 确定有助于加速生物衰老的特定PFAS.
主要方法:
- 利用了来自中国国家人类生物监测计划的9756名参与者的数据.
- 使用Klemera-Doubal方法 (KDM) 和Mahalanobis距离 (MD) 计算生物年龄.
- 根据13个食物组的消费频率评估了DDS;使用加权定量和回归分析了PFAS混合物效应.
主要成果:
- 大多数PFAS与KDM-age加速 (KDM-AA) 有积极的关联.
- 在低度的PFAS中,剂量反应关系更为.
- PFHpS和PFNA被确定为KDM-AA和MD的主要贡献者;DDS可能改变了PFAS与衰老的关联.
结论:
- PFAS暴露与加速的生物衰老有显著的关联.
- 更高的DDS可能会减轻PFAS对生物衰老的不良影响.
- 饮食多样性是对抗PFAS诱导的衰老的潜在预防措施.
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