Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Molecular Models02:00

Molecular Models

37.6K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
37.6K
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

4.3K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
4.3K
Fischer Projections02:18

Fischer Projections

12.8K
Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines.
12.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

deMEM: a novel divide-and-conquer framework based on de Bruijn graph for scalable multiple sequence alignment.

GigaScience·2026
Same author

DeCoST: unveiling cell type heterogeneity in spatial transcriptomics based on inter-domain alignment and Gaussian kernel conditional autoregressive.

Briefings in bioinformatics·2025
Same author

Cancer Drug Sensitivity Prediction Based on Deep Transfer Learning.

International journal of molecular sciences·2025
Same author

EPIPDLF: a pretrained deep learning framework for predicting enhancer-promoter interactions.

Bioinformatics (Oxford, England)·2025
Same author

FORAlign: accelerating gap-affine DNA pairwise sequence alignment using FOR-blocks based on Four Russians approach with linear space complexity.

Briefings in bioinformatics·2025
Same author

SpaCcLink: exploring downstream signaling regulations with graph attention network for systematic inference of spatial cell-cell communication.

BMC biology·2025
Same journal

Erratum for the Research Article "Assessing the health risks of rice cadmium content standards in China" by H. Chu <i>et al</i>.

Science advances·2026
Same journal

Erratum for the Research Article "Developmental regulation of Erk signaling by mitotic kinases" by F. Chen <i>et al</i>.

Science advances·2026
Same journal

Magnetically levitated metasurface enabling tangible and bidirectional human-machine interaction.

Science advances·2026
Same journal

A general photoinduced manganese-catalyzed platform for the sequential difunctionalization of [1.1.1]propellane.

Science advances·2026
Same journal

Turning sound and force into light with AlN:Mn<sup>2+</sup> mechanoluminescence.

Science advances·2026
Same journal

Extreme dominance of Earth-origin heavy ions in the intense ring current near the Earth during the May 2024 super geomagnetic storm.

Science advances·2026
查看所有相关文章

相关实验视频

Updated: May 13, 2025

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

7.8K

多尺度图表等价扩散模型用于3D分子设计.

Lu Chen1, Yan Li2, Yanjie Ma1

  • 1School of Computer Science and Technology, Xidian University, Xi'an 710071, Shaanxi, China.

Science advances
|April 16, 2025
PubMed
概括
此摘要是机器生成的。

本研究引入了一种新的多尺度图形等价扩散模型 (MD3MD) 用于3D分子设计. MD3MD产生多样,稳定和创新的分子,通过增强的化学太空探索推进药物发现.

更多相关视频

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix
09:26

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

8.5K
Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy
12:15

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy

Published on: April 9, 2019

8.6K

相关实验视频

Last Updated: May 13, 2025

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

7.8K
Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix
09:26

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

8.5K
Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy
12:15

Image Processing Protocol for the Analysis of the Diffusion and Cluster Size of Membrane Receptors by Fluorescence Microscopy

Published on: April 9, 2019

8.6K

科学领域:

  • 计算化学是一种计算化学.
  • 药物发现 药物发现
  • 机器学习用于分子设计.

背景情况:

  • 当前的3D分子生成方法在准确的结构表示方面存在困难.
  • 点云和简化的模型限制了生成的分子的忠实性.

研究的目的:

  • 开发一种先进的模型,用于高质量的3D分子生成.
  • 提高设计用于药物发现的分子的精度和多样性.

主要方法:

  • 提出了多尺度图表等效扩散模型 (MD3MD).
  • 分区分子构造成多尺度图形,加权原子相互作用.
  • 使用由多尺度图形框架指导的扩散过程.

主要成果:

  • MD3MD在无条件和条件3D分子生成中表现出卓越的性能.
  • 产生的分子是多样化的,稳定的,创新的,满足特定条件.
  • 视觉化证实了模型学习特定领域模式和生成新型分子的能力.

结论:

  • MD3MD在3D分子设计方面取得了重大进展.
  • 该模型有效地探索化学空间,产生化学上多样化和创新的分子.
  • 在为药物设计生成高质量的3D分子结构方面,MD3MD超越了现有的方法.