艾滋病毒和癌症风险之间的关联:全国范围的基于人口的队列研究
Tak Kyu Oh1,2, Kyoung-Ho Song3,4, Eunjeong Heo5
1Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
AIDS (London, England)
|April 16, 2025
概括
艾滋病毒感染者 (PLWH) 患有艾滋病确定的癌症 (ADC) 的风险明显更高. 虽然整体非艾滋病确定的癌症 (NADC) 风险相似,但PLWH面临特定的NADC风险增加,如鼻和门癌.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 人类免疫缺陷病毒 (HIV) 感染会影响免疫功能,可能会改变癌症风险.
- 了解艾滋病毒感染者 (PLWH) 癌症发病率对于公共卫生和临床管理至关重要.
- 韩国的特定的人口和医疗保健环境需要针对PLWH进行量身定制的癌症风险评估.
研究的目的:
- 调查和比较韩国艾滋病毒感染者 (PLWH) 和艾滋病毒阴性个体之间的癌症发病率.
- 通过将它们分为艾滋病定义癌症 (ADC) 和非艾滋病定义癌症 (NADC) 来区分癌症风险.
主要方法:
- 使用基于人口的队列研究设计.
- 包括来自韩国 (2017-2022) 的20703个PLWH和89881个倾向分数匹配的对照.
- 癌症诊断 (ADC和NADC) 被评估为终点.
主要成果:
- 与对照组相比,PLWH的ADC发病率高出3.17倍 (165.9对每10万人年51.8).
- 在PLWH和对照组之间没有发现NADC发生率的显著整体差异 (P=0.101).
- 对于特定的NADCs,PLWH显示了高风险:鼻癌,门癌,非黑色素瘤皮肤癌,霍奇金淋巴瘤和白血病.
结论:
- 携带艾滋病毒 (PLWH) 的人面临着艾滋病定义癌症 (ADC) 的风险大幅增加.
- 特定的非艾滋病定义癌症 (NADCs),包括鼻,门和皮肤癌,以及某些淋巴瘤和白血病,在PLWH中更为普遍.
- 这些发现凸显了针对PLWH进行向癌症监测和预防策略的需要.
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