乳二烯可以增强骨感染中黄金葡萄球菌的抗生素治疗
Jillian Cornish1, Reece Joseph1, Jian-Ming Lin1
1Department of Medicine, University of Auckland, Auckland, New Zealand.
概括
牛乳酸 (bLf) 增强了抗生素对 Staphylococcus aureus 生物膜的有效性,为治疗骨髓炎等慢性骨感染提供了新的希望.
科学领域:
- 骨再生医学 骨再生医学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 生物膜对大约65%的感染和80%的慢性感染有贡献.
- 对甲基西林敏感的金黄色葡萄球菌 (MSSA) 生物膜对抗生素表现出显著的耐受性,使骨感染的治疗复杂化.
- 塞法林 (CEF) 的疗效对MSSA生物膜是有限的,尽管在浮游生物细胞中具有敏感性.
研究的目的:
- 调查牛乳酸 (bLf) 在增强抗生素治疗黄金菌骨感染的潜力.
- 评估bLf对MSSA生物膜耐受性对塞法林 (CEF) 的影响.
主要方法:
- 在体外培养的MSSA生物膜.
- 评估了MSSA生物膜对单独的CEF和与BLf结合的敏感性.
- 确定了在存在bLf时生物膜根除所需的CEF的最小抑制度 (MIC).
主要成果:
- 与浮游生物细胞相比,MSSA生物膜对CEF的耐受性是1000倍的.
- 添加bLf使得CEF耐受性MSSA生物膜在CEF的10倍MIC时可以被根除.
- 乳酸的已知刺激骨生长的特性增强了它对骨感染的治疗吸引力.
结论:
- 牛乳酸 (bLf) 显著增强了对黄金菌生物膜的素 (CEF) 的疗效.
- bLf提出了一种有前途的治疗策略,用于对抗抗生素耐受性骨感染.
- 在促进骨生长和抗击感染方面,bLf的双重作用使其成为骨再生医学中宝贵的药物.
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