在精神病过渡期间的氧化应激标志物
Victoria Rambaud1, Ariel Frajerman2, Margot Fournier3
1Université Paris Cité, INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
Journal of psychiatric research
|April 16, 2025
概括
血液中氧化应激的生物标志物可以预测超高风险 (UHR) 个体的精神病过渡. 较低的抗氧化剂百氧化-4水平表明风险降低,而GPx活性和TBARS与症状严重程度相关.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 精神病学是一个精神病学.
背景情况:
- 超高风险 (UHR) 状态识别了患精神病风险较高的个体.
- 大多数UHR个体不会转变为精神病,因此需要预测生物标志物.
- 氧化还原失调与精神病障碍的病理生理学有关.
研究的目的:
- 调查血液氧化应激标志物与UHR个体中精神病过渡之间的关联.
- 识别可以预测过渡到精神病的外围氧化还原标记.
- 探索氧化应激标志物与症状严重程度之间的关系.
主要方法:
- 血液样本从48名UHR个体在基线和12个月的随访或过渡时收集.
- 评估了各种氧化还原标记物,包括谷氨系统,超氧化脱酶,硫素,TBARS,过氧素-4,MMP9和sRAGE.
- 在非转换者 (UHR-NC) 和转换者 (UHR-C) 中分析了标志物演变为精神病.
主要成果:
- 一组外周氧化还原标记在基线时区分了UHR-C和UHR-NC.
- 血中过氧化-4水平的降低与精神病过渡的风险较低有关.
- 谷氨过氧化酶 (GPx) 活性和TBARS水平与以后的症状严重程度相关.
结论:
- 外周氧化应激生物标志物显示出在UHR个体中监测精神病过渡风险的潜力.
- 这些发现支持开发针对氧化还原通路的治疗方法,以预防和治疗精神病.
- 这些生物标志物可能有助于早期检测和个性化风险评估.
相关概念视频
Psychological and Sociocultural Causes of Schizophrenia
37
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
37
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
285
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
285
Introduction to Stress and Lifestyle
50
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
50
Psychological Responses to Stress
28
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
28
Mania and Antimanic Drugs: Overview
103
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
103
Aging
29
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
29


