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Updated: May 13, 2025

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
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阻止视网膜微质的抗原呈现功能阻断了由树突细胞主导的CD4+ T细胞引起的自身免疫神经炎症

Shintaro Shirahama1, Yoko Okunuki2, May Y Lee2

  • 1Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts, USA; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.

Journal of autoimmunity
|April 16, 2025
PubMed
概括

微质细胞,而不是树突细胞,通过重新刺激眼中的T细胞来驱动自身免疫性脑膜炎. 向微质细胞提供了一种新的治疗策略,以预防或减少这种导致失明的原因.

关键词:
呈现抗原的细胞.树突性细胞 树突性细胞实验性的自身免疫性脑膜炎.在MHCII类中,MHC是II类.微质细胞中的微质细胞视网膜 (retina) 是一个视网膜.

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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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