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Updated: May 13, 2025

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
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Published on: June 27, 2018

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通过DNA结合和线粒化保护多重胺蛋白质免受组合的形成

Shady Saad1, Tomek Swigut1, Saman Tabatabaee1

  • 1Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Cell
|April 16, 2025
PubMed
概括

像FOXP2这样的转录因子中的多重胺 (polyQ) 长通道通过DNA结合或酸化保持溶解. 人类特异性的FOXP2变化减少了其聚合,为多Q疾病提供了治疗见解.

关键词:
其他类型亨廷顿病粉样蛋白演变的过程富含谷氨酸的蛋白质人类语言语言多聚胺蛋白质组件转录因子

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