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线粒体新陈代谢维持DNMT3A-R882突变的克隆性血液形成

Malgorzata Gozdecka1,2, Monika Dudek3,4, Sean Wen4,5

  • 1Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. mg717@cam.ac.uk.

Nature
|April 16, 2025
PubMed
概括

针对线粒体代谢可以预防急性髓性白血病 (AML) 的进展. 在英国生物库的一项研究中,甲胺抑制了DNMT3A- R882突变细胞的扩张,并与较低的CH患病率有关.

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