来自家禽菌株的益生菌联盟,用于支持对病原体的肠道免疫力
Guldana Boranbayeva1, Zhanar Tekebayeva2, Aslan Temirkhanov2
1Republican Collection of Microorganisms of the Committee of Science, Ministry of Education and Science of the Republic of Kazakhstan, 13/1 Valikhanov Str., Astana, 010000, Kazakhstan; Department of Environmental Engineering and Management, Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, 2 Satpayev Str., Astana, 010000, Kazakhstan.
Microbial pathogenesis
|April 16, 2025
概括
这项研究表明,多菌株益生菌KMK3改善肉生长和免疫力. KMK3增强了病原体耐药性和肠道健康,为家禽生产提供了一个有前途的方法.
科学领域:
- 禽畜科学 禽畜科学 禽畜科学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 多菌株益生菌通过调节肠道微生物群和免疫反应来增强宿主健康.
- 益生菌越来越多地被认为对病原体耐药性和宿主整体福祉的作用.
研究的目的:
- 为了评估一种新的三种菌株联合体KMK3 (Lactobacillus brevis TN9,Ligilactobacillus salivarius F9/2,Ligilactobacillus salivarius TL4/1) 在肉中的益生菌疗效.
- 调查KMK3对病原体耐药性,免疫调节和肠道健康的影响,特别是在沙门氏菌肠道挑战下.
主要方法:
- 评估KMK3联盟中个别菌株的生长动力学.
- 向肉施用KMK3并评估生长性能,料转化率 (FCR) 和对沙门氏菌肠道的血清抗体标位.
- 通过测量细胞因子水平 (IL-10,IL-1β,TNF-α) 和检查肠道组织病理学 (恶高度,免疫细胞透) 来分析免疫反应.
主要成果:
- KMK3显著改善了13%的体重增加,并增强了FCR (1.50对1.75).
- 通过提高IL-10的调节和抑制IL-1β和TNF-α,KMK3提高了针对Salmonella enterica的血清抗体标位,并调节了免疫反应.
- 用KMK3治疗的显示出改善的肠道组织病理学,包括增加的高度和减少免疫细胞透,即使在沙门氏菌挑战期间.
结论:
- 多菌株益生菌KMK3有效提高肉的生长性能和免疫功能.
- 在改善病原体耐药性和肠道健康方面,KMK3显示出显著的潜力,为家禽健康管理提供了宝贵的工具.
- 这些发现强调了KMK3在缓解传染病挑战和通过针对性宿主病原体相互作用和免疫调节来提高家禽生产率方面的治疗潜力.
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