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多部位跨脑磁性刺激与脉冲宽度调制.

Heikki Sinisalo1, Mikael Laine1, Jaakko O Nieminen1

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概括
此摘要是机器生成的。

多位点TMS (mTMS) 与脉冲宽度调制 (PWM) 可实现更快的准. 虽然使用2-3个线圈是有效的,但五个线圈显示了电机响应的一些差异,表明毫秒级控制的可行性.

关键词:
电场时间的过程.运动皮层刺激运动皮层刺激多线圈的TMS是多线圈的神经元脱极化的神经元脱极化脉冲宽度调制的方法波形是指波形的波形形式.

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科学领域:

  • 神经科学是一个神经科学.
  • 生物医学工程 生物医学工程

背景情况:

  • 超磁刺激 (TMS) 使用头皮线圈来诱导电场以激活神经元.
  • 多位点TMS (mTMS) 允许电子控制刺激位置和方向.
  • 当前的mTMS线圈调整限制了目标变化到秒.

研究的目的:

  • 调查微秒级脉冲宽度调制 (PWM) 对于快速的多线圈TMS准.
  • 评估PWM在克服mTMS速度限制方面的有效性.

主要方法:

  • 开发了一种用于生成和驱动PWM参考脉冲近似值的方法.
  • 在形脉冲和PWM脉冲之间比较静止电机值 (RMTs) 和电机唤起的电位 (MEPs).
  • 在各种多线圈准场景中评估性能.

主要成果:

  • PWM脉冲表现出高度的时间复杂性.
  • 对于2或3线圈组合,没有发现RMT或MEP的显著差异.
  • 五线圈PWM刺激显示,在较高剂量下,RMT增加了9% (p=0.06) 和MEP幅度减少了20% (p<0.05).

结论:

  • 使用mTMS的PWM脉冲可用于毫秒级别的目标控制.
  • 对于带有2-3卷的形脉冲和PWM脉冲,运动反应是相同的.
  • 需要进一步研究增加线圈数量的神经生理学影响.