贝叶斯基准剂量评估在怀孕期间与化物质和多化物质暴露相关的甲状腺功能障碍
Shiwen Li1, Jingguang Li2, Yongning Wu3
1College of Food Science and Engineering, Hubei Key Laboratory for Processing and Transformation of Agricultural Products, Wuhan Polytechnic University, Wuhan, Hubei, 430023, China.
概括
产前暴露在per-和多醇基物质 (PFAS) 中可能会破坏母亲的甲状腺功能. 研究表明,特定的PFAS,如PFHxS和高甲状腺刺激激素 (TSH) 之间存在关联,突出了甲状腺平衡的风险.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 有限且不一致的流行病学数据存在于孕产妇甲状腺功能因产前暴露的甲状腺功能障碍.
- 甲状腺激素,包括自由甲状腺素 (FT4) 和甲状腺刺激激素 (TSH),在怀孕期间对母亲和胎儿的健康至关重要.
研究的目的:
- 为了研究产前PFAS暴露对母体甲状腺功能标记物的影响:FT4,TSH,甲状腺过氧化酶抗体 (TPOAb) 和FT4/TSH比率.
- 估计基准剂量 (BMD) 值用于风险评估,并确定甲状腺干扰的临界暴露水平.
主要方法:
- 在单个和混合污染物模型中使用线性回归和邦费罗尼校正来评估PFAS和甲状腺功能之间的关联.
- 采用贝叶斯核心机器回归 (BKMR) 混合效应模型来评估复杂的污染物相互作用.
- 计算的BMD值,以确定人类健康风险评估的参考点.
主要成果:
- 在 perfluorohexanesulfonic acid (PFHxS) 暴露和母亲的TSH水平之间发现了显著的正相关性.
- PFAS暴露与FT4/TSH比率的变化有关.
- 由于PFBA和PFHxS导致的TSH升高的基准剂量水平分别确定为0.33 ng/mL和0.28 ng/mL.
结论:
- 产前暴露于PFASs,特别是PFHxS,与母亲甲状腺功能中断有关,特别是TSH升高.
- 骨质检查结果表明,目前对某些PFAS的暴露水平可能会对甲状腺平衡构成风险.
- 在PFAS风险评估中优先考虑内分泌终点是非常重要的,因为它对甲状腺功能的影响已经确定.
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