基于胺的风险评分:一种新的实验室工具,用于高尿血和痛风中心血管风险分层
Aleš Kvasnička1, David Friedecký1, Barbora Piskláková1
1Laboratory for Inherited Metabolic Disorders, Department of Clinical Biochemistry, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacký University Olomouc, Czech Republic.
痛风和高尿血症增加了心血管疾病的风险. 冠状动脉事件风险测试 (CERT) 确定了这些患者的风险较高,建议其用于更好的风险分层和有针对性的干预措施.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 痛风和高尿血与心血管疾病 (CVD) 风险增加有关.
- 有效的风险分层对于管理这些疾病和预防心血管疾病事件至关重要.
研究的目的:
- 评估冠状动脉事件风险测试 (CERT) 在高尿血和痛风患者心血管风险评估中的有用性.
- 在这些患者群体中探索CERT得分,血陶胺,炎症和动脉动脉指数之间的关联.
主要方法:
- 试点研究涉及94名高尿血患者,196名痛风患者和53名对照.
- 使用液体染色学-质谱学分析的等离子体陶.
- 评估了冠状动脉事件风险测试 (CERT) 的得分.
主要成果:
- 高CERT分数 (≥7) 在11.7%的高尿素血症患者和31.12%的痛风患者中观察到,与对照组相比分别增加了2倍和5.5倍.
- 患有CERT分数升高的患者表现出更高的炎症水平和血动脉质指数.
- 在高尿血症和痛风队列中,炎症和动脉动脉指数与CERT分数有显著的相关性.
结论:
- 冠状动脉事件风险测试 (CERT) 显示,在患有痛风和高尿血症的患者中,心血管风险分层增强的潜力.
- 将CERT纳入临床实践可能有助于识别针对性预防策略的高风险个体.
- 需要进一步的研究来验证CERT在这些人群中控制心血管风险方面的作用.
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