生命末期妄想中的循环节律:对两项随机对照试验的二次分析
Sonal Admane1, Sarah Pasyar2, Roland Bassett2
1Department of Palliative (S.A., E.B., D.H.), Integrative and Rehabilitation Medicine, The University of Texas, MD Anderson Cancer Center, Houston, Texas.
Journal of pain and symptom management
|April 16, 2025
概括
临终狂妄症患者在下午更容易感到不安,特别是下午3点到11点之间. 这一发现与"日落"一致,可以帮助临床医生更有效地预测和管理这种症状.
科学领域:
- 抚慰性护理是一种缓解性护理.
- 老年医学 老年医学
- 神经科学是一个神经科学.
背景情况:
- 生命末期狂妄症患者的昼夜不安模式尚不清楚.
- 焦虑是晚期癌症和狂妄症患者的常见和令人痛苦的症状.
研究的目的:
- 研究癌症晚期和生命末期妄症患者突破性不安的时间.
- 为了确定与增加的不安相关的特定时间间隔.
主要方法:
- 对两项随机临床试验 (MAD和CHAD) 的二次分析,这些试验涉及临终狂妄症患者.
- 通过救援药物管理和里士满兴奋镇静量表 (RASS) 评分 (≥+1) 评估的不安.
- 在8小时间隔分析不安频率:上午7点至下午3点,下午3点至下午11点,下午11点至上午7点.
主要成果:
- 在两个试验中,在下午3点到下午11点之间发现了显著的关联,并且增加了用于不安的救援药物的使用.
- 下午3点至下午11点的间隔也与MAD试验中RASS分数≥+1更频繁的发作有关.
- 在多变量分析中,这些关联仍然显著.
结论:
- 在生命末期经历狂妄症的患者在下午3点至晚上11点之间表现出增加的不安.
- 这种模式,类似于"日落",可以帮助临床医生预测和管理不安.
- 这些发现支持改善症状监测,治疗安排和患者/护理人员教育.
相关概念视频
02:19Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
01:19Management of Insomnia
229
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
229