相关实验视频
Updated: May 13, 2025
10:09
Operation of the Collaborative Composite Manufacturing CCM System
Published on: October 1, 2019
6.5K
一个通用的数字控制概念,用于端到端制造.
L Kuchler1, A Azimi2, H Damiri3
1Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010 Graz, Austria.
International journal of pharmaceutics
|April 16, 2025
概括
先进的制造需要实时的过程控制. 本研究介绍了使用数字双胞胎和软传感器的灵活控制概念,用于复杂的制药生产,确保高速操作的质量.
科学领域:
- 制药制造业 制药制造业 制药制造业
- 工艺控制工程 工艺控制工程
- 先进的制造系统是先进的制造系统.
背景情况:
- 现代制药制造业面临的复杂性增加,先进的概念,如连续加工和模块化设计.
- 传统的质量控制方法对于高速制造是不够的,需要实时监控和控制.
- 现有的控制策略往往缺乏适应各种加工,设备和自动化设置的灵活性.
研究的目的:
- 为复杂的制造工艺提供一种普遍适用的控制概念.
- 展示灵活的控制策略,适应批量和连续操作,手动和自动化系统,以及不同的设备尺度.
- 在现实世界的一条端到端的制药生产线中验证控制概念.
主要方法:
- 开发一种集成批量和连续工艺的普遍适用的控制概念.
- 实施一个紧的,端到端的平板电脑制造线,包括API合成,结晶,过,洗和配方.
- 使用一种控制策略,结合过程分析技术 (PAT) 传感器,设备数据和软传感器,与基于模型的控制的数字双胞胎集成.
主要成果:
- 在制药生产线上成功展示了控制概念.
- 通过软传感器和料数据有效监测和控制产品质量.
- 将流程和质量信息集成到数字双胞胎中,以执行基于模型的控制策略.
结论:
- 提出的控制概念为复杂的制造环境提供了高水平的控制和灵活性.
- 数字双胞胎方法与多种数据源相结合,可以实现实时流程和质量管理.
- 这种策略适用于先进的制药制造,解决了传统控制方法的局限性.
相关概念视频
01:10Control Systems
962
Control systems are everywhere in contemporary society, influencing diverse applications from aerospace to automated manufacturing. These systems can be found naturally within biological processes, such as blood sugar regulation and heart rate adjustment in response to stress, as well as in man-made systems like elevators and automated vehicles. A control system is essentially a network of subsystems and processes that collaboratively convert specific inputs into desired outputs.
At the heart...
At the heart...
962
01:25Control Systems: Applications
524
Electrical engineering plays a pivotal role in our daily lives, with control systems at the heart of many applications, from home appliances to sophisticated space shuttles. Control systems manage and regulate the behavior of devices and processes, ensuring they function safely, correctly, and efficiently.
In modern vehicles, control systems manage various functions to enhance performance and safety. The steering wheel and accelerator are primary inputs in a car's control system. The...
In modern vehicles, control systems manage various functions to enhance performance and safety. The steering wheel and accelerator are primary inputs in a car's control system. The...
524
01:17Open and closed-loop control systems
567
Control systems are foundational elements in automation and engineering. They are broadly categorized into open-loop and closed-loop systems. These classifications hinge on the presence or absence of feedback mechanisms, significantly influencing the system's performance, complexity, and application.
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal...
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal...
567
01:26Feedback control systems
256
Feedback control systems are categorized in various ways based on their design, analysis, and signal types.
Linear feedback systems are theoretical models that simplify analysis and design. These systems operate under the principle that their output is directly proportional to their input within certain ranges. For instance, an amplifier in a control system behaves linearly as long as the input signal remains within a specific range. However, most physical systems exhibit inherent nonlinearity...
Linear feedback systems are theoretical models that simplify analysis and design. These systems operate under the principle that their output is directly proportional to their input within certain ranges. For instance, an amplifier in a control system behaves linearly as long as the input signal remains within a specific range. However, most physical systems exhibit inherent nonlinearity...
256
01:19Electro-mechanical Systems
876
Electromechanical systems are intricate configurations that effectively combine electrical and mechanical elements to achieve a desired outcome. Central to many of these systems is the DC motor, a device that converts electrical energy into mechanical motion, enabling various applications ranging from simple fans to complex robotic mechanisms.
A key component of the DC motor is the armature, a rotating circuit positioned within a magnetic field. As an electric current passes through the...
A key component of the DC motor is the armature, a rotating circuit positioned within a magnetic field. As an electric current passes through the...
876
01:22Controller Configurations
72
Controller configurations are crucial in a car's cruise control system because they manage speed over time to maintain a consistent pace regardless of road conditions, thereby meeting design goals. In traditional control systems, fixed-configuration design involves predetermined controller placement. System performance modifications are known as compensation.
Control-system compensation involves various configurations, most commonly series or cascade compensation, in which the controller...
Control-system compensation involves various configurations, most commonly series or cascade compensation, in which the controller...
72