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Updated: May 12, 2025

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions
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Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

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基于PAR结合蛋白的全蛋白体微阵列查

Bong Gu Kang1,2, Sung-Ung Kang1,2, Jae Jin Kim3,4

  • 1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.

Nucleic acids research
|April 16, 2025
PubMed
概括

研究人员确定了356种与Poly (ADP-ribose) (PAR) 结合的蛋白质,揭示了它在DNA修复之外的细胞信号传递中的广泛作用. 这一发现扩大了我们对各种生物过程中PARylation的理解.

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PAR-CliP - A Method to Identify Transcriptome-wide the Binding Sites of RNA Binding Proteins12:24

PAR-CliP - A Method to Identify Transcriptome-wide the Binding Sites of RNA Binding Proteins

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相关概念视频

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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