囊炎病变的细胞和分子机制:不仅仅是微生物群
Manuel B Braga-Neto1,2, Taha Qazi3, Clifton Fulmer4
1Department of Gastroenterology, Hepatology & Nutrition, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA braganm@ccf.org.
Gut
|April 16, 2025
概括
皮囊炎,皮质囊的炎症,尽管接受了抗生素治疗,但往往会复发. 本综述探讨了超越微生物组的复杂原因,包括遗传学和免疫功能障碍,并提出了新的治疗方法.
科学领域:
- 胃肠道学和免疫学
- 炎症性肠道疾病的发病原因
背景情况:
- 炎是性结肠炎的恢复性直肠切除术后最常见的并发症.
- 目前的抗生素疗法往往不足,导致复发性或耐药性疾病.
- 这强调了需要更深入地了解囊病理生理学的必要性.
研究的目的:
- 审查潜在的机制背后的囊炎.
- 讨论目前的动物模型及其局限性.
- 探索新的治疗策略和疾病模型.
主要方法:
- 对囊炎机制的文献综述,包括遗传,微生物组,屏障和免疫因素.
- 对现有的动物模型进行分析,以进行炎研究.
- 讨论新出现的概念,如转移性疾病和非免疫细胞的作用.
主要成果:
- 炎涉及复杂的相互作用:遗传倾向,微生物组失调,肠道屏障缺陷和免疫系统失调.
- 新出现的证据表明,毛囊炎可能是一种涉及树皮细胞的转移性疾病.
- 目前的动物模型可能无法完全回顾人类口袋炎的复杂性.
结论:
- 皮囊炎的发病因子是多因素的,扩展到超出皮囊微生物组之外.
- 非免疫细胞和超神经炎症是潜在的关键因素.
- 需要新的多细胞疾病模型来推进治疗发炎的治疗方法.
相关概念视频
Inflammatory Bowel Disease V: Surgical Management
65
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
65
Chronic Bowel Disorders: Introduction
319
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
319
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
479
Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
479
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
306
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
306
Inflammatory Bowel Disease I: Ulcerative Colitis
98
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
98
Inflammatory Bowel Disease II: Crohn's Disease
129
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
129


