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怀孕前的肥胖,不良的怀孕结果和中年心血管疾病风险
Jaclyn D Borrowman1, Xiaoning Huang1, Lucia C Petito1
1Northwestern University, Chicago, Illinois, USA.
Journal of the American College of Cardiology
|April 16, 2025
概括
不良妊娠结果 (APOs) 部分介绍了孕前肥胖和中年心血管疾病 (CVD) 风险之间的联系. 在怀孕前控制体重对于长期的母亲心血管健康至关重要.
科学领域:
- 生殖健康 生殖健康
- 心血管健康 心血管健康
- 代谢健康 代谢健康
背景情况:
- 怀孕前的肥胖是妊娠不良结果 (APO) 和心血管疾病 (CVD) 的重要危险因素.
- APO作为身体质量指数 (BMI) 和心血管疾病风险之间的标记物或调解者的作用仍然不清楚.
研究的目的:
- 量化APO在怀孕前BMI和中年心血管疾病风险因素之间的关联中介的程度.
- 研究妊娠糖尿病 (GDM) 和新发妊娠高血压障碍 (HDP) 在这种关系中的调解作用.
主要方法:
- 从高血糖和不良妊娠结果随访研究 (HAPO FUS) 队列的数据分析.
- 包括没有妊娠前高血压或糖尿病的孕妇参与者 (≥18岁),分娩后11.6年的随访.
- 调整多个共同变量的调解分析,评估自我报告的孕前BMI和中年心血管疾病风险因素 (MAP,甘油三,HbA1c).
主要成果:
- 与正常BMI相比,患有妊娠前肥胖症 (10.6%) 的参与者表现出更高的中年MAP,甘油三和HbA1c.
- 妊娠期糖尿病 (GDM) 在肥胖和HbA1c之间的关联中部分介于24.6%.
- 新发性妊娠高血压障碍 (HDP) 部分介导了12.4%的肥胖和MAP之间的关联.
结论:
- 妊娠前不良结果 (APO) 中介在妊娠前肥胖和中年心血管疾病风险之间的联系中占有很小但很大的比例.
- 怀孕前的体重管理对于促进长期的母亲心血管健康至关重要.
- 这凸显了早期生命过程干预对于预防未来心血管疾病的重要性.
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