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神经肌肉电刺激对凝血和心血管因素的急性影响
Johanna Flodin1,2, Stefan M Reitzner3,4, Nida Mahmoud Hourani Soutari5,6
1Integrative Orthopaedic Laboratory, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Physiological genomics
|April 16, 2025
概括
神经肌肉电刺激 (NMES) 略微增加了血液凝固状态,类似于运动,而不会增加凝血风险. 此外,NMES还影响参与炎症调节的心血管蛋白.
科学领域:
- 生理学 生理学 生理学
- 生物医学工程 生物医学工程
背景情况:
- 预防静脉血栓栓塞是一个关键问题.
- 神经肌肉电刺激 (NMES) 是一种潜在的干预措施.
- 它对凝血和心血管因素的影响需要澄清.
研究的目的:
- 为了研究2小时NMES会话对凝血和心血管因素的急性影响.
- 评估NMES应用后立即发生的变化.
主要方法:
- 36名健康参与者接受了为期2小时的NMES课程,使用子中的集成织电极.
- 凝血因子 (整体静血潜力,纤维素原,XIII因子) 和蛋白质性心血管因子在会议前后被测量.
- 在亚最大强度 (16.5-25.4 mA) 应用NMES时,可接受的不适 (VAS < 4).
主要成果:
- 观察到整体静血潜力和凝血潜力的显著增加.
- 观察到整体纤维溶解潜力的下降.
- 变化与纤维素因子增加有很强的相关性,但与因子VIII不相关.
- 92种与炎症和细胞外矩阵重塑相关的心血管蛋白中的18种受到NMES的影响.
结论:
- 一个2小时的NMES会话会诱导一种轻微的促凝状态,与定期炼相当.
- 这些变化在正常范围内,不太可能增加凝血风险.
- NMES影响心血管蛋白质,可能对未来研究的炎症反应产生调节作用.
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