在老鼠和人类中,thalamic反会塑造皮质刺激引起的大脑反应
Simone Russo1,2,3,4, Leslie D Claar3, Giulia Furregoni1,5
1Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, Milan, 20157, Italy.
Nature communications
|April 16, 2025
概括
单脉冲皮质刺激会触发皮质下电路,在人类和小鼠中揭示类似的唤起潜力 (EP). 一个晚期的EP组件是由于大理石过极化和反弹而产生的,受网络状态的影响.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
背景情况:
- 单脉冲皮质刺激在研究和临床环境中广泛使用.
- 皮层刺激对皮层下回路的参与及其对唤起潜能 (EP) 的贡献仍然不完全理解.
研究的目的:
- 为了研究由单脉冲皮质刺激引起的皮质下电路.
- 确定唤起潜力的后期组件背后的机制.
- 探索对刺激的皮质 - thalamic 电路反应的跨物种保护.
主要方法:
- 在皮层刺激后,人类和小鼠的唤起潜能 (EP) 的比较.
- 在小鼠中神经回路的光遗传剖析.
- 泰拉莫皮层电路模拟.
主要成果:
- 皮质刺激在人类和小鼠中引起了类似的EP,其中一个晚期组件由皮质 - thalamic网络状态调节.
- 光遗传学实验显示,晚期的EP组件是由thalamic超极化和反弹驱动的.
- 晚期组件的大小与乳头神经元爆发频率和同步性相关,受行为状态的影响.
结论:
- 单脉冲皮质刺激会触发皮质-甲状腺-皮质电路.
- 观察到的电路参与和响应概况在很大程度上保持在物种和刺激方式之间.
- thalamic内在电流和GABAergic神经元在塑造唤起的潜在反应中起着至关重要的作用.
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