饮食模式和结直肠癌:在伊朗人口中进行的多中心病例控制研究
Michele Sassano1, Monireh Sadat Seyyedsalehi1,2, Maryam Hadji3,4
1Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Scientific reports
|April 16, 2025
概括
西式饮食和高含不健康脂肪的饮食与增加结肠直肠癌 (CRC) 风险有关. 建议减少不健康食品的摄入量,特别是那些含有高和和脂肪酸的食物.
科学领域:
- 营养科学 营养科学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 饮食模式 (DPs) 和结直肠癌 (CRC) 之间的关系尚不清楚.
- 调查饮食对CRC的影响对于公共卫生至关重要.
- 之前的研究已经产生了关于特定饮食模式和CRC风险的不确定的结果.
研究的目的:
- 在伊朗人口中评估饮食模式和结肠直肠癌 (CRC) 之间的关联.
- 为了确定可能增加或减少CRC风险的特定饮食模式.
- 通过饮食为CRC预防提供基于证据的建议.
主要方法:
- 在伊朗 (2017-2020年) 进行了一项基于多中心医院的病例控制研究.
- 主要成分因子分析和降低等级回归 (RRR) 用于推导饮食模式 (DPs).
- 调整的几率比率 (ORs) 和95%置信区间 (CI) 计算了DP四分位数的CRC风险,并进行了FDR校正.
主要成果:
- 西式饮食与增加CRC风险有显著的关联 (ORQ4vsQ1 = 4.15;p趋势< 0.001).
- 高含不健康脂肪的饮食模式,以高动物产品摄入为特征,也显示出与CRC的积极关联 (ORQ4vsQ1 = 2.14;p趋势<0.001).
- 这些关联在CRC子站点和各种参与者特征中保持一致,包括吸烟和片使用.
结论:
- 西式饮食和富含不健康脂肪的饮食都与患结直肠癌的风险更高有关.
- 减少不健康食物的摄入量,特别是那些高含和和脂肪酸的食物,可能是预防CRC的关键策略.
- 对特定的食品成分及其在CRC病因学中的作用进行进一步的研究是有必要的.
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