在基于人口的队列研究中,身体圆度指数和2型糖尿病发病率之间的关联
1School of Exercise and Health, Shanghai University of Sport, 200 Hengren Road, Yangpu, Shanghai, 200438, China.
Scientific reports
|April 16, 2025
概括
较高的身体圆度指数 (BRI) 与中国成年人患2型糖尿病 (T2D) 的风险增加有关. 这一发现表明,BRI可能有助于T2D预防战略.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 生物统计学 生物统计学
背景情况:
- 关于身体圆度指数 (BRI) 和2型糖尿病 (T2D) 之间的关联,国家数据有限.
- 了解这种关系对于制定有效的公共卫生战略至关重要.
- 中国健康与退休长度研究 (CHARLS) 为这项调查提供了有价值的数据集.
研究的目的:
- 检查BRI与发展T2D的风险之间的关联.
- 调查BRI和T2D之间的潜在非线性关系.
- 评估BRI作为中国人口T2D风险预测指标的实用性.
主要方法:
- 利用了来自CHARLS (2011-2020) 的10,785名参与者的数据.
- 采用Cox比例危险模型和限制立方线 (RCS) 来进行统计分析.
- 分析了BRI重复测量和T2D病例,平均随访时间为7.72年.
主要成果:
- 在BRI和T2D风险之间发现了显著的积极关联.
- 每次1-SD增加的BRI与27%更高的T2D风险相关 (HR:1.27).
- 观察到非线性关系,BRI=3.96的拐点,之后T2D风险显著增加 (HR:1.29).
结论:
- 升高的BRI与中年和老年中国人的T2D风险增加显著相关.
- BRI可以作为T2D风险评估的有价值的生物标志物.
- 将BRI纳入临床和公共卫生战略可以有助于减轻T2D负担.
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