胃癌联合项目 (StoP) 项目中的鱼类消费和胃癌
Carlotta Franchi1,2, Ilaria Ardoino3, Sara Mandelli3
1Laboratory of Pharmacoepidemiology and Human Nutrition, Department of Health Policy, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri, 2, 20156, Milano, Italy. carlotta.franchi@marionegri.it.
Scientific reports
|April 16, 2025
概括
这次元分析发现,鱼类消费与整体胃癌风险之间没有联系. 然而,在亚洲,鱼类摄入与较低的胃癌风险有关,特别是当调整为家族病史或H. pylori感染时.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 营养科学 营养科学
背景情况:
- 胃癌是全球癌症死亡的主要原因之一.
- 了解饮食风险因素对于预防策略至关重要.
研究的目的:
- 评估鱼/鱼消费与胃癌风险之间的关联.
- 探索这个协会的地理差异.
主要方法:
- 对25项病例控制研究 (10,431例,24,903例) 的元分析.
- 聚合几率比率 (OR) 计算了鱼类和头鱼的摄入量.
- 进行的敏感性分析调整了诸如H. pylori感染等共变量.
主要成果:
- 总体鱼类消费与胃癌风险之间没有显著的关联 (OR=0.99,95% CI 0.86-1.13).
- 增加鱼类摄入量显示亚洲人群的风险降低.
- 在调整了家族病史 (OR=0.80) 和H. pylori (OR=0.72) 的情况下,鱼类消费与较低的风险有关.
- 对于头鱼的消费没有发现任何关联 (OR=0.96,95% CI 0.82-1.13).
结论:
- 鱼类和装鱼类的摄入量通常与胃癌风险无关.
- 存在地理差异,在亚洲人群中观察到潜在的保护作用.
- 进一步的研究可能会澄清鱼类在胃癌预防中的作用,考虑到区域因素.
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