相关实验视频

Updated: May 11, 2025

Assessment of Child Anthropometry in a Large Epidemiologic Study

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

MC4-R 变种证实了其与儿童到青春期的进展过程中与肥胖的关联

Angelika Mohn¹, Armando Di Ludovico², Nella Polidori²

¹Paediatric Department, University of Chieti "G. D'Annunzio", 66100, Chieti, Italy. amohn@unich.it.

Scientific reports

|April 16, 2025

概括

靠近黑色素皮质素受体4 (MC4-R) 的rs12970134变体与青少年的肥胖有关. 这种肥胖的遗传风险因素从童年到青春期一直存在.

科学领域:

遗传学遗传学是一个
内分泌学在内分泌学.
儿科儿科儿科

背景情况:

在黑色素皮质蛋白受体4 (MC4-R) 附近的rs12970134变体已经显示出对肥胖的年龄相关影响.
以前的研究将这种变种与8岁以上的青春期前儿童的肥胖症联系起来.

研究的目的:

调查MC4-R基因的rs12970134变异是否有助于青春期肥胖.
评估MC4-R rs12970134变异对体重指数和肥胖症的长期影响.

主要方法:

在8年的随访后,从以前的研究中对参与者的纵向人体测量评估.
在MC4-R基因型 (AA,AG,GG) 中比较BMI-SDS,腰围和超重/肥胖百分比.
根据他们的MC4-R基因型对青少年受试者的匹配分析.

主要成果:

与GG和AG基因型相比,AA风险基因型在基线和随访时与更高的BMI-SDS和腰围有关.
具有AA基因型的受试者在访问之间BMI-SDS没有显著变化,与AG和GG基因型不同,这些基因型下降.
与AG和GG基因型相比,AA基因型的个体中超重/肥胖的比例更高.

结论:

接近MC4-R的rs12970134变种不仅对青春期前儿童产生肥胖原性影响,而且在青春期也是一个重要的风险因素.
这种遗传变异在肥胖的长期发展和持续中起着至关重要的作用.

关键词:

青少年青少年青少年在MC4-R中,我们可以看到MC4-R.在MC4-R风险等位基因中.肥胖问题肥胖问题体重过重的情况

更多相关视频

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

相关概念视频

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...

Nature and Nurture

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...