与GLP-1受体激动剂相关的男性性功能障碍:对FAERS数据的横截面分析
Ashkan Pourabhari Langroudi1, Abby L Chen1, Satvir Basran1
1Department of Urology, School of Medicine, Stanford University, Stanford, CA, USA.
International journal of impotence research
|April 16, 2025
概括
葡萄糖类-1 (GLP-1) 受体激动剂与男性性功能障碍,包括勃起功能障碍和性欲下降的弱相关性. 随着GLP-1使用的增加,建议进行监测,但患者的整体风险似乎很低.
科学领域:
- 药物监督 药物监督 药物监督
- 内分泌学 在内分泌学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 葡萄糖类-1 (GLP-1) 受体激活剂已成为2型糖尿病和肥胖症的治疗方法.
- 虽然已被认为有代谢益处,但潜在的不良影响需要持续调查.
研究的目的:
- 调查GLP-1受体激动剂与男性性功能障碍之间的关联.
- 分析与这些药物相关的高潮功能障碍,勃起功能障碍和性欲下降报告的病例.
主要方法:
- 利用了FDA不良事件报告系统 (FAERS) 从2003年第四季度到2024年第一季度的数据.
- 使用OpenVigil 2.1平台进行数据分析,计算不成比例度 (ROR,PRR,RRR) 并应用埃文斯标准.
- 确定了182例涉及GLP-1受体激动剂的病例 (蒂尔泽帕提德,塞马格卢提德,杜拉格卢提德,埃克塞纳提德,利克西塞纳提德,利拉格卢提德).
主要成果:
- 大多数受影响的患者年龄在40-60岁之间,糖尿病是最常见的症状 (43.9%).
- 埃克萨纳提德和塞马格卢提德是最常见的GLP-1受体激活剂.
- 尽管有统计学显著的发现 (P < 0.0001),但报告的低概率比率 (ROR),比例报告比率 (PRR) 和相对报告比率 (RRR) 显示出一个弱的关联.
结论:
- 这项研究表明GLP-1受体激动剂与男性性功能障碍之间存在弱相关性.
- 随着这些药物的使用扩大,建议继续进行药监.
- 对患者的整体风险似乎很低.
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