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Updated: Jun 16, 2025

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

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深度视觉蛋白质组测绘遗传性肝病中的蛋白质毒性

Florian A Rosenberger1, Sophia C Mädler2, Katrine Holtz Thorhauge3,4

  • 1Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany. rosenberger@biochem.mpg.de.

Nature
|April 16, 2025
PubMed
概括

这项研究使用先进的蛋白质组学揭示了α-1-抗素缺乏症 (AATD) 中的关键分子事件. 它确定了早期的过氧体变化和明显的晚期细胞表型,为蛋白质错折疾病提供了新的见解.

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Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

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相关概念视频

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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