绘制宏观和微量营养素在骨矿物质密度中的作用:一项全面的门德尔随机化研究
Rong Xiang1, Xunying Zhao2, Linna Sha1
1Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
European journal of nutrition
|April 16, 2025
概括
低维生素B12和水平与骨矿物质密度降低有关,增加骨质疏松症风险. 保持这些营养素的最佳水平对于骨健康和预防骨损失至关重要.
科学领域:
- 营养科学 营养科学
- 骨的新陈代谢 骨的新陈代谢
- 遗传流行病学遗传流行病学
背景情况:
- 营养素摄入量,包括宏观营养素和微量营养素,与骨质疏松症的发展有关.
- 之前的观察性研究报告了有关营养物质与骨质疏松症相关的不一致的发现.
- 建立因果关系对于制定有效的营养策略来预防骨质疏松症至关重要.
研究的目的:
- 调查宏观营养素摄入量和循环中的微量营养素水平对估计骨矿物质密度 (eBMD) 的因果关系.
- 为了利用大规模的全基因组关联研究 (GWAS) 总结统计数据进行强大的孟德尔随机化 (MR) 分析.
- 为了确定与EBMD因果相关的特定营养素,这是骨质疏松风险的标志物.
主要方法:
- 通过使用最大的可用的GWAS总结统计数据进行了两样本的门德尔随机化 (MR) 分析.
- 评估了对能量调整的大量营养素 (脂肪,蛋白质,碳水化合物,糖) 和20种循环微量营养素 (维生素和矿物质) 的因果影响.
- 进行了敏感性,性别特异性和单样MR分析,用于结果验证和稳定性检查.
主要成果:
- 观察到维生素A,维生素B12,维生素E和与eBMD的循环水平之间存在暗示性关联.
- 维生素B12和对eBMD的因果作用在邦费罗尼校正后仍然显著,并且独立于混因素.
- 确定了维生素E和eBMD之间的男性特异性因果关系;然而,一个样本的MR没有发现饮食营养摄入量和eBMD之间的因果关系.
结论:
- 最佳的血维生素B12和血清水平对于减轻骨质损失和改善骨健康至关重要.
- 这些发现强调了通过营养建议保持足够的维生素B12和水平的重要性.
- 准这些微量营养素可能有助于促进eBMD,并作为预防骨质疏松症的战略.
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