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饮食因素和口腔癌风险:在欧洲人口中进行全面的门德尔随机化分析

Shiyang Zhao¹, Xichen Liu¹, Qingsen Wang¹

¹Department of Stomatology, Jining Medical University, Shandong, 272067, China.

Discover oncology

|April 16, 2025

概括

某些酒精饮料和小麦制品可能会增加口腔癌 (OCC) 的风险,而新鲜和干燥的水果显示有保护作用. 这项研究使用了门德尔的随机化来探索这些与OCC的饮食联系.

科学领域:

口腔和大面部外科手术
营养流行病学营养流行病学
遗传流行病学遗传流行病学

背景情况:

口腔癌 (OCC) 是一种常见的恶性瘤,已知与烟草和酒精有关.
饮食越来越被认为是OCC发展的重要因素,但因果关系需要进一步阐明.
两个样本的门德尔随机化 (MR) 分析被用于调查特定饮食模式和OCC风险之间的潜在因果关系.

研究的目的:

估计六种不同的饮食习惯对患口腔癌 (OCC) 的风险的因果关系.
识别可能增加或减少OCC风险的特定饮食成分.
探索潜在的调解途径,包括人类特征,系统和代谢物,在饮食-OCC关系中.

主要方法:

进行了两样本的孟德尔随机化 (MR) 分析,使用与饮食暴露相关的遗传变异.
暴露包括香/白葡萄酒,红葡萄酒,干果,新鲜水果,酒/酒和小麦产品的消费.
口腔癌 (OCC) 总结统计数据是从全基因组关联研究 (GWAS) 中获得的;反变异加权 (IVW) 是主要分析方法,辅以加权中位数和MR-Egger,并进行了灵敏度分析.

主要成果:

香/白酒,酒/酒,红酒和小麦制品的消费与OCC的风险增加有关.
新鲜水果和干水果的消费表明对OCC有保护作用.
调解分析表明,尾肌肉质量,站立高度,甲状腺功能低下,消化系统疾病和脂质概况在饮食-OCC关系中的作用.

结论:

特定的饮食模式,包括饮用某些酒精饮料和小麦制品,可能会增加OCC风险.
相反,新鲜和干燥水果的消费可以提供对OCC的保护.
这些发现突出了通过饮食影响OCC风险的潜在途径,为未来的预防和治疗策略提供了信息.

关键词:

饮食饮食饮食饮食全基因组关联研究研究.门德尔的随机化口腔癌是一种口腔癌.单个核酸的多态性.

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