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糖化代谢物预测了艾滋病毒感染的老年人发生的与年龄相关的并发病和死亡率

Xi Qiao¹, Liangliang Zhang^1,2, Emely A Hoffman³

¹Department of Population and Quantitative Health Sciences, Case Western Reserve Univ, Cleveland, OH, USA.

|April 16, 2025

概括

先进的糖化最终产品 (AGEs) 与衰老有关. 在艾滋病毒感染者中,更高的AGE预测了并发症,而像谷氨这样的排毒代谢物预测了更低的风险,这表明了潜在的干预措施.

科学领域:

生物化学和分子生物学
免疫学和传染病的研究
老年学和老年医学是老年学和老年医学.

背景情况:

糖化是一种非酶反应,形成先进的糖化最终产品 (AGEs),与与年龄有关的疾病有关.
艾滋病毒-1感染会改变细胞代谢以致糖解,可能增加AGE的形成和相关的并发症.
在治疗艾滋病毒患者的临床结果预测中,AGE及其解毒途径的作用仍在研究中.

研究的目的:

调查基线血AGE度及其解毒代谢物的预测性关联与发生的并发症和艾滋病患者在抗逆转录病毒治疗中的死亡率.
探索特定的AGEs (甲基素,3-脱氧糖) 和它们的代谢物 (谷氨,谷氨酶产物) 作为潜在的生物标志物.

主要方法:

一项前性多中心队列研究,涉及376名接受抗逆转录病毒治疗的参与者.
在基线收集的血样本使用液态染色体质谱分析了AGE和排毒代谢物.
追踪了事件的临床结果,包括糖尿病,慢性病,神经认知障碍和全因死亡率.

主要成果:

甲基氧衍生的AGE的较高基线度预测了糖尿病,慢性病和反复跌倒的风险增加.
升高的3-脱氧葡萄预测了外围神经病变的风险增加.
谷氨和谷氨糖酶循环产品度的增加与糖尿病,神经认知障碍,虚弱,骨折,反复跌倒和全因死亡率的风险降低有关.

结论:

基线血AGE及其解毒代谢物可预测HIV感染者发生的并发症和死亡率.
研究结果表明,减少糖化或增强谷氨通路可能会减轻这一群体与年龄相关的衰退.
这项研究突出了针对艾滋病毒管理中的糖化和氧化应激治疗干预的潜力.

关键词:

高级糖化最终产品的高级糖化.脱氧葡萄糖是一种脱氧葡萄糖.葡萄糖氨酸 (Glutathione) 是一种葡萄糖溶解是什么? 葡萄糖溶解格利奥沙酶循环中的一个.乳糖氨酸-乳糖氨酸是一种乳酸.乳酸氨酸蛋白质是一种乳酸氨酸蛋白质.甲基格里奥克萨尔 (Methylglyoxal) 是一种

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