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绿色振动光谱方法用于同时量化散装和片剂配方的抗高血压药物

Naga Prashant K¹, Suvarna Yenduri²

¹Faculty of Pharmacy, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagara, Karnataka, India.

Scientific reports

|April 16, 2025

概括

这项研究引入了一种绿色的FT-IR方法,用于在药物中量化安洛迪平甲基酸盐 (AML) 和特尔米沙坦 (TEL). 这种环保的方法确保了药物分析的准确性,同时减少了浪费,避免了有毒溶剂.

科学领域:

分析化学分析化学
绿色化学绿色化学
频谱学是一种光谱学.

背景情况:

制药分析通常涉及产生大量废物和使用有毒溶剂的方法.
需要在药物量化中使用环境可持续的分析技术.

研究的目的:

开发和验证一个环保的FT-IR光谱光度测量方法,用于同时量化阿姆洛迪平甲基酸盐 (AML) 和特尔米沙坦 (TEL).
为了使药物定量与绿色分析化学原则保持一致.

主要方法:

使用富里埃变换红外 (FT-IR) 光谱光度与压颗粒技术使用化.
用于药物定量的吸收光谱曲线下的使用面积.
根据ICH指南验证了该方法.

主要成果:

通过FT-IR方法,成功量化了混合配方中的AML和TEL.
特定的AML和TEL峰值分别在1206厘米-1和863厘米-1被确定.
对这两种药物实现了低检测极限 (LOD) 和量化极限 (LOQ),表明高灵敏度.
方法验证证实了在可接受范围内的结果.
绿色评估模型 (MoGAPI,AGREE prep,RGB) 证实了该方法的可持续性.

结论:

开发的FT-IR方法是一个可行的,绿色的替代方案,用于同时量化AML和TEL.
这种方法支持绿色分析化学原则,而不会影响分析性能.
该方法简单,快速,环保,减少浪费,避免有毒溶剂.

关键词:

阿姆洛迪平氨酸是如何使用的曲线下的面积曲线下的面积生态友好型的环保型在FTIR光谱学中使用.定量分析是一种量化分析.泰尔米沙坦 (Telmisartan) 是一种药物.

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