冠状动脉疾病使心力衰竭患者的过度死亡率增加一倍,其排气分数减少
Nanna Anker1, Kevin K W Olesen1,2, Pernille G Thrane1,2
1Department of Cardiology Aarhus University Hospital Aarhus Denmark.
Journal of the American Heart Association
|April 16, 2025
概括
冠状动脉疾病 (CAD) 显著增加了心力衰竭的死亡率,减少了喷射率 (HFrEF) 的患者. 评估CAD对于预后至关重要,因为与一般人群相比,它会使过度死亡率增加一倍.
科学领域:
- 心脏病学 心脏病学
- 临床研究 临床研究
- 公共卫生 公共卫生
背景情况:
- 冠状动脉疾病 (CAD) 的评估在心力衰竭中与减少喷射率 (HFrEF) 患者在全球范围内有所不同.
- 关于CAD在这个人群中的长期影响的数据有限.
- 这项研究调查了HFrEF患者接受冠状动脉血管造影的CAD和死亡率之间的关联.
研究的目的:
- 为了检查冠状动脉疾病 (CAD) 和全因死亡率之间的关联.
- 为了比较HFrEF患者与无CAD之间的死亡率.
- 为了比较HFrEF患者与CAD的死亡率与匹配的一般人群.
主要方法:
- 利用丹麦登记册来识别接受冠状动脉血管学 (2003-2016) 的HFrEF患者 (EF ≤40%).
- 估计的10年累积发病率和调整的风险比率 (aHR) 对于所有原因的死亡.
- 将患有CAD的HFrEF患者与没有CAD的患者以及与年龄/性别相匹配的一般人群进行比较 (1:5比).
主要成果:
- 包括3294名HFrEF患者 (44%患有CAD) 和16365名普通人群个人.
- 患有HFrEF和CAD的患者的10年死亡率 (55%) 比没有CAD的患者 (33%) 高.
- 与普通人群相比,HFrEF患者的CAD存在使10年死亡率增加了一倍 (55%对26%).
结论:
- 冠状动脉疾病 (CAD) 的存在和程度与HFrEF患者的死亡率密切相关.
- 在HFrEF中改善预后,CAD评估至关重要.
- 在HFrEF患者中识别和管理CAD可以显著影响长期结果.
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