在无痛结肠镜检查技术中,纳尔布芬和水墨的比较疗效和安全性:一项随机对照试验
Chunliu Hou1, Siming Zhang1, Yuqing Zhu1
1Postgraduate Training Institute of Jizhou District People's Hospital,Tianjin Medical University, No. 18, Nanhuan Road, Jizhou District, Tianjin, 301900, People's Republic of China.
纳尔布非因在结肠镜检查期间提供了比摩更好的术后舒适性. 这项研究发现,纳尔布芬减少了恶心和吐等副作用,使其成为无痛结肠镜的首选选择.
科学领域:
- 麻醉学 麻醉学
- 胃肠病学 胃肠病学
- 临床药理学 临床药理学
背景情况:
- 结肠镜对于诊断结肠病变至关重要,但通常会引起患者的不适.
- 无痛结肠镜技术旨在改善患者体验,但需要仔细管理血液动力学变化和术后反应.
- 在无痛的结肠镜检查过程中,需要最佳的止痛指导.
研究的目的:
- 为了比较nalbuphine和hydromorphone在提高结肠镜检查期间患者舒适度方面的疗效和安全性.
- 评估这些止痛药在手术期间对血液动力学稳定性的影响.
- 为无痛结肠镜临床实践提供最佳的止痛药指导.
主要方法:
- 一项前性,随机,双盲控制试验,涉及72名接受镇静结肠镜检查的成年患者.
- 随机分配患者接受纳尔布芬 (0.13毫克/千克) 或摩 (0.016毫克/千克),并根据需要给予普罗波.
- 持续监测生命体征,记录手术时间,记录不良反应和满意度.
主要成果:
- 在结肠镜检查期间,纳尔布非因和水利摩尔都有效地保持了血液动力学稳定性 (P > 0.05).
- 与水利摩尔相比,纳尔布芬显著降低了手术后恶心,吐,头和头痛的发生率 (P < 0.05).
- 纳尔布非因表现出优越的术后舒适度,报告的副作用较少.
结论:
- 在结肠镜检查期间,纳尔布芬和水力对维持手术内生命体征有效.
- 纳尔布芬提供卓越的术后舒适性,使其成为门诊结肠镜检查中首选的止痛药.
- 需要进一步的研究来优化剂量,并阐明两种药物在程序性疼痛管理中的作用机制.
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