疼痛强度与焦虑,注射速度和眼内压力变化在静脉内抗血管内皮生长因子注射期间的关系:观察试点研究
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Published on: July 23, 2016
31.6K
Ali Kurt1, Emin Utku Altındal2
1Ophthalmology Department, Alanya Alaaddin Keykubat University Education and Research Hospital, Antalya, Turkey. dralikurt@gmail.com.
BMC ophthalmology
|April 16, 2025
概括
焦虑和眼内压力 (IOP) 变化在抗血管内皮生长因子 (anti-VEGF) 注射期间显著影响疼痛. 更快的注射速度与更少的疼痛相关,而更高的焦虑和IOP差异增加了疼痛的严重程度.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗血管内皮生长因子 (anti-VEGF) 的静脉内注射 (IVI) 是对视网膜疾病的常见治疗方法.
- 在IVI期间患者的舒适度对于坚持和整体治疗经验至关重要.
研究的目的:
- 调查抗VEGF IVI期间疼痛严重程度与注射速度,患者焦虑程度和眼内压力 (IOP) 变化等因素之间的相关性.
- 确定IVI患者经历的疼痛的主要决定因素.
主要方法:
- 一项前性研究涉及84个眼睛,这些眼睛是接受静脉注射贝瓦西祖马布或拉尼祖马布治疗的未经治疗的患者.
- 用视觉模拟量表 (VAS) 评估疼痛的严重程度,用贝克焦虑量表测量焦虑程度.
- 在IVI手术前后记录眼内压力 (IOP).
主要成果:
- 在注射速度和VAS得分之间发现了显著的负相关性 (p=0.024).
- 注射后的IOP差异 (p=0.001) 和焦虑水平 (p<0.001) 都与疼痛严重程度 (VAS) 有显著的正相关性.
- 焦虑和IOP差异被确定为影响疼痛的最有影响力的因素,贝瓦西祖马布IVI与统计学上显著的疼痛比拉尼祖马布 (p=0.005) 更大.
结论:
- 患者的焦虑和注射后的IOP变化是抗VEGFIVI期间疼痛的最重要的预测因素.
- 较慢的注射速度与减少疼痛感知有关.
- 了解这些因素可以帮助优化患者管理,改善IVI体验.
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