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胰岛素类生长因子1与肥胖儿童左心室质量指数之间的相关性
Wanxia Niu1, Chen Li2, Zhaorui Wang3
1Department of Pediatrics, Shandong Public Health Clinical Center, Shandong University, Jinan, 250013, China.
BMC endocrine disorders
|April 16, 2025
概括
患有较低胰岛素样生长因子1 (IGF-1) 水平的肥胖儿童显示左心室质量指数 (LVMI) 增加,这是心血管风险标志物. 监测IGF-1可能有助于在这个人群中早期发现心血管问题.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 心血管健康 心血管健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 低胰岛素样生长因子1 (IGF-1) 与心血管疾病有关.
- 儿童肥胖与降低IGF-1水平有关.
- 肥胖儿童的IGF-1和左心室质量指数 (LVMI) 之间的关系尚未得到充分证实.
研究的目的:
- 调查IGF-1水平与肥胖儿童的LVMI之间的相关性.
- 评估肥胖儿科人群中的心血管风险因素.
主要方法:
- 研究了104名肥胖儿童和61名健康对照.
- 测量包括人体测量,IGF-1,心血管代谢因子和心声回声学以确定LVMI.
- 统计分析对胆固醇,甘油三和尿酸等混因素进行了控制.
主要成果:
- 肥胖儿童的LVMI高,IGF-1标准偏差分数 (SDS) 低于对照组.
- 在IGF-1 SDS和LVMI之间发现了显著的负相关性 (β = -0.161,p = 0.046).
- 胰岛素耐药性 (HOMA-IR) 与LVMI (β = 0.241,p = 0.007) 有正相关性.
结论:
- 在肥胖儿童中,IGF-1和LVMI是独立的负相关的.
- 监测IGF-1可能有助于确定肥胖儿童的心血管风险.
- 根据这些发现,可以制定早期干预策略.
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