圆度指数 (C指数),相对脂肪量 (RFM) 和骨关节炎 (OA) 之间的关联:来自NHANES 2003-2018年的证据
Xiaodong Ren1,2, Junxiang Wang1,2, Jiachen Wang1,2
1Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, 710054, China.
Lipids in health and disease
|April 16, 2025
概括
肥胖增加了骨关节炎 (OA) 的风险. 新的测量方法,圆度指数 (C指数) 和相对脂肪量 (RFM),显示了与OA的显著关联,较高的水平与风险增加有关.
科学领域:
- 医学研究 医学研究
- 公共卫生 公共卫生
- 生物统计学 生物统计学
背景情况:
- 肥胖是骨关节炎 (OA) 的重要危险因素.
- 圆度指数 (C指数) 和相对脂肪量 (RFM) 是用于评估肥胖的新兴人体测量指标.
- 了解这些肥胖指标与OA之间的联系对于风险预测至关重要.
研究的目的:
- 调查度指数 (C指数) 和相对脂肪质量 (RFM) 与骨关节炎 (OA) 之间的关联.
- 探索这些肥胖度和OA患病率之间的非线性关系和子组相互作用.
主要方法:
- 利用了来自全国健康和营养检查调查 (NHANES) 的数据,共有34,707名参与者.
- 采用多变量逻辑回归和受限立方线 (RCS) 分析.
- 进行了子组相互作用分析,以检查OA与肥胖相关的变化.
主要成果:
- 较高的C指数 (OR=1.60) 和RFM (OR=2.07) 四分位数与增加的OA风险有显著联系.
- C指数和OA之间的关系非线性,而RFM显示线性关联.
- 观察到显著的子组相互作用效应,表明人口之间存在差异性风险.
结论:
- C指数和RFM显示与骨关节炎有显著的关联.
- 这些新型的人类测量措施可以作为评估OA风险的有价值指标.
- 对这些肥胖指标的进一步研究可以改进OA预防策略.
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