呼吸系统症状集群中的全因和因特定死亡率:基于人口的多队列研究
Daniil Lisik1, Helena Backman2, Hannu Kankaanranta3,4,5
1Krefting Research Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. daniil.lisik@gu.se.
Respiratory research
|April 16, 2025
概括
成年人常见的呼吸道症状形成了不同的群体,一些显著增加死亡风险. 识别这些症状组对于了解健康结果和潜在的未诊断疾病至关重要.
科学领域:
- 流行病学 流行病学
- 呼吸系统医学 呼吸系统医学
- 生物统计学 生物统计学
背景情况:
- 呼吸系统症状在一般成年人群中很普遍.
- 较高的呼吸道症状负担可能与增加的死亡风险有关.
- 这项研究调查了呼吸系统症状和死亡率之间的关联.
研究的目的:
- 在大量成年人群中识别出不同的呼吸系统症状集群.
- 评估这些已识别的症状集群与全因和因特定死亡率之间的关联.
- 为了确定这些症状集群的临床相关性,与诊断的呼吸道疾病相关.
主要方法:
- 利用了两个基于人口的瑞典成年人队列 (N=63,060) 的数据.
- 应用局部敏感哈希 (LSH) -k-原型用于对报告至少一个呼吸道症状的个体进行集群分析.
- 链接死亡记录数据 (超过60万人/年) 来评估关联,使用无症状个体作为参考组.
主要成果:
- 超过60%的人报告至少有一个呼吸道症状;约30%的人报告五个或更多.
- 确定了五个症状集群,包括"低症状"",过敏鼻症状"",过敏鼻症状与喘息和呼吸障碍发作"",喘息和呼吸障碍发作"以及"反复产生咳和喘息".
- 除了"过敏鼻症状"之外,所有都与全因死亡率有关. 集群"喘息和呼吸困难发作"和"经常性生产性咳和喘息"显示出与呼吸道死亡率的最强相关性.
结论:
- 在一般成年人群中存在不同的呼吸道症状集群.
- 这些症状集群通过与死亡率差异相关,证明了临床相关性.
- 确定的症状集群与已诊断的呼吸道疾病的相关性很弱,这表明潜在的未被诊断的疾病.
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