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Updated: May 14, 2025

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
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和酸诱导mTORC1驱动的综合应激反应,有助于肝细胞中的葡萄糖脂毒性

Rui Guo1, Yanhui Li1, Yuwei Jiang2

  • 1Department of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, Illinois, United States.

American journal of physiology. Gastrointestinal and liver physiology
|April 17, 2025
PubMed
概括

肝脏葡萄糖脂毒性涉及通过mTORC1-eIF2α-ATF4通路的Palmitate诱导的综合应激反应 (ISR) 激活. 高葡萄糖通过增加和酸的基质来加剧这种情况,从而放大细胞死亡.

关键词:
这就是ISRR.葡萄糖脂质毒性 葡萄糖脂质毒性在 mTORC1 的情况下,mTORC1 是棕酸盐是一种棕酸盐.亚酸是酸中的一种.

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