益生菌改善细颗粒物空气污染暴露的参与者的肺功能和QOL:一个随机,双盲,安慰剂控制的临床试验
Yongcan Wu1,2, Caixia Pei3, Xiaomin Wang3
1Chongqing College of Traditional Chinese Medicine, Chongqing, 402760, PR China.
Food & function
|April 17, 2025
概括
益生菌改善了暴露于细颗粒物 (PM2.5) 的个体的肠道微生物群多样性和肺功能. 这种干预改善了生活质量和像FEV1这样的肺指标,提供了对PM2.5毒性的潜在策略.
科学领域:
- 微生物学 微生物学
- 肺部病理学 肺部病理学
- 环境健康 环境健康
背景情况:
- 益生菌可以通过肠肺轴减轻肺炎.
- 有限的研究存在于益生菌对PM2.5诱导的肺毒性的作用.
- 调查益生菌对PM2.5暴露的影响对于公共卫生至关重要.
研究的目的:
- 评估亲生菌对PM2.5暴露个体的肺功能和生活质量的影响.
- 探索肠道微生物群的机制,从而获得益生菌的益处.
- 为了评估 Lactobacillus rhamnosus GG (LGG) 益生菌的干预作用.
主要方法:
- 120名志愿者每天接受LGG益生菌或安慰剂4周,随后进行6个月的监测.
- 协差分析和混合线性模型被用于分析数据.
- 评估了肠道微生物群多样性 (香农指数,β多样性) 和肺功能 (FEV1,FEF50%,FEF75%).
主要成果:
- 益生菌干预积极改变了肠道微生物群的多样性 (香农指数,β多样性).
- 干预后和随访期间,生活质量得分显著改善.
- 肺功能关键指标 (FEV1,FEF50%,FEF75%) 与安慰剂相比显示出显著差异.
结论:
- 益生菌干预可以调节肠道微生物群的组成.
- 在长期暴露于PM2.5的个体中,LGG益生菌显示出改善生活质量的潜力.
- 益生菌可能为缓解PM2.5相关的呼吸道问题提供治疗途径.
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