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肠道微生物群,炎症性细胞因子和急性胰腺炎之间的潜在因果关系:孟德尔的随机化研究
Xiaofeng Wang1,2, Yiwen Qiu3, Ying Di4
1Department of Critical Care Medicine, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi, China.
这项研究发现了与急性胰腺炎 (AP) 风险相关的特定肠道细菌. 虽然有些细菌会增加AP风险,但有些细菌会降低AP风险,但炎症性细胞因子不会调解这种联系.
科学领域:
- 胃肠病学 胃肠病学
- 遗传学 是一个遗传学.
- 微生物组研究 微生物组研究
背景情况:
- 急性胰腺炎 (AP) 是一种常见的胃肠道紧急情况.
- 新出现的证据突出显示了肠道微生物群 (GM),炎症性细胞因子和AP发育之间的相互作用.
研究的目的:
- 使用孟德尔随机化研究肠道微生物群,炎症性细胞因子和急性胰腺炎之间的潜在因果关系.
- 探索炎症性细胞因子在肠道微生物群-AP轴中的调解作用.
主要方法:
- 一项两样本的门德尔随机化 (MR) 研究使用了GM (n=18,340),细胞因子 (n=8293) 和AP (3022例,195,144例对照) 的总结统计数据.
- 逆方差加权 (IVW) 方法是主要的,MR-Egger和加权中位数作为灵敏度分析.
- 敏感性分析包括Cochran的Q测试,MR-Egger拦截,离开一个,和MR-PRESSO来评估性和异质性.
主要成果:
- 几种转基因种群与AP风险有显著的关联:Bacteroidales,Eubacterium fissicatena群和Coprococcus3具有积极的关联,而Prevotella9,RuminococcaceaeUCG004和Ruminiclostridium6具有负面的关联.
- 巨菌群刺激因子 (M-CSF) 是唯一与AP负相关的细胞因子.
- 调解分析表明M-CSF没有调解GM和AP之间的关系.
结论:
- 特定的肠道微生物组合因果关系与急性胰腺炎风险有关.
- 虽然M-CSF显示了与AP的反向关联,但它并没有调解肠道微生物群对AP发育的影响.
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